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透明质酸(HA)是结缔组织的主要成分,特别在软骨及滑膜中含量较高,近来有报告表明,进行性系统性硬化症(PSS)患者的氨基葡萄糖聚糖(GAG)代谢异常,血清透明质酸(SHA)升高,尿 GAG 排泄增加,本文对 SHA 与 PSS 的关系进行了进一步探讨。31例 PSS 患者,以掌指关节为界,按皮肤受侵范围分为两组:近端 PSS 和远端PSS。近端 PSS15例,平均年龄50.9±11.8岁,平均病程12.3年;远端 PSS16例,平均年龄50.1±7岁,平均病程14.6年,相同年
Hyaluronic acid (HA) is the main component of connective tissue, especially in cartilage and synovium. Recent reports indicate that glucosaminoglycan (GAG) is abnormal in patients with progressive systemic sclerosis (PSS) Serum hyaluronic acid (SHA) increased, urinary GAG excretion increased, the relationship between SHA and PSS was further explored in this paper. Thirty-one PSS patients were divided into two groups according to the range of skin invasion: the proximal PSS and the distal PSS. The proximal PSS15 cases, mean age 50.9 ± 11.8 years, the average duration of 12.3 years; distal PSS16 cases, the average age of 50.1 ± 7 years, the average duration of 14.6 years, the same year