曾认为5羟色胺的释放是偏头痛的主要病因。近年的研究提示,偏头痛发作的原因可能是脑血痉挛(也有可能动静脉短路)而表现为脑缺血和缺氧。为此,对一系列保护脑缺氧的药物进行筛选发现,flunarizine通过抑制Ca~(++)进入血管平滑肌细胞,有助于解释它预防偏头痛的疗效。本文报道口服flunarizine的作用。 Serotonin release was thought to be the main cause of migraine. Recent studies suggest that the cause of migraine attacks may be cerebral blood spasm (also possible arteriovenous short circuit) and the performance of cerebral ischemia and hypoxia. To this end, screening a series of drugs that protect brain hypoxia found that flunarizine helps to explain the efficacy of migraine against migraine by inhibiting Ca ~ (++) entry into vascular smooth muscle cells. This article reports the role of oral flunarizine.