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检侧了２０例小儿手术期间肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡｇⅡ）。醛固酮（ＡＬＤ）及皮质醇（ＣＯＲ）的变化。氯胺酮安定静脉麻醉下，分别于麻醉前、麻醉后２０ｍｉｎ，切皮后５ｍｉｎ，３０ｍｉｎ及术后１ｈ，２４ｈ分取５ｍｌ静脉血，检测ＰＲＡ，ＡｇⅡ，ＡＬＤ，ＣＯＲ含量的变化。结果：麻醉后２０ｍｉｎ的ＣＯＲ值较对照值增高（Ｐ＜００５）切皮后５ｍｉｎ，３０ｍｉｎ和６０ｍｉｎ的ＡＬｄ，Ｃｏｒ值均较对照值有显著性增高（Ｐ＜００５或＜００１），且切皮后５ｍｉｎ，３０ｍｉｎ和６０ｍｉｎＡＬＤ，ＣＯＲ值均明显高于麻醉后２０ｍｉｎ值（Ｐ＜００１）。直至手术后２４ｈ时的ＡＬＤ值仍分别较对照值和麻醉后２０ｍｉｎ值有高度显著性（Ｐ＜００１）。提示本麻醉法不能阻止手术的伤害性剌激，引起应激效应激素的分泌过度增加。
Check the 20 cases of pediatric surgery during renin activity (PRA), angiotensin Ⅱ (Ag Ⅱ). Aldosterone (ALD) and cortisol (COR) changes. Ketamine stable intravenous anesthesia before anesthesia, 20min after anesthesia, 5min after skin incision, 30min and 1h, 24h after taking 5ml venous blood were measured PRA, Ag Ⅱ, ALD, COR content changes. Results: The COR values at 20 min after anesthesia were significantly higher than those at the control (P <005). The values of AL and Cor at 5 min, 30 min and 60 min after incision were significantly higher than those of the control (P <005 or <0 01). The COR values at 5 min, 30 min and 60 min after incision were significantly higher than those at 20 min after anesthesia (P <001). The ALD values up to 24 hours after operation were still significantly higher than those of control and 20 minutes after anesthesia (P <001). Tip of the anesthetic method can not prevent the noxious stimulation of surgery, causing excessive secretion of stress-responsive hormones.