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目的:研究多囊卵巢综合征(PCOS)临床内分泌代谢对于子宫内膜病变的影响。方法:收集2010年1月至2014年1月,我院收治的PCOS患者68例,分为PCOS伴子宫内膜病变组(A组)与子宫内膜正常组(B组),选择同期非卵巢障碍性不孕或者卵巢良性肿瘤患者30例作为对照组,检测并比较三组的血清内分泌激素水平、胰岛素以及血糖。结果:A组高雄雌激素血症发生率31.2%,与B组的33.3%无明显差异(P>0.05);A组胰岛素抵抗率75.0%,显著高于B组38.9%(P<0.05);三组血清E2无明显差异(P>0.05);A、B组T、LH/FSH及HOMA-IR显著高于对照组(P<0.05)。结论:PCOS患者合并高胰岛素血症是引起子宫内膜的主要原因,胰岛素水平增高可能促进子宫内膜异常增生。
Objective: To study the effect of clinical endocrine and endocrine metabolism of polycystic ovary syndrome (PCOS) on endometrial lesions. Methods: Sixty-eight PCOS patients admitted to our hospital from January 2010 to January 2014 were divided into group PCOS with endometriosis (group A) and group with normal endometrium (group B). The patients with non-ovarian Obstructive infertility or benign ovarian tumors in 30 patients as a control group to detect and compare the three groups of serum endocrine hormone levels, insulin and blood glucose. Results: The incidence of estrogen in Kaohsiung was 31.2% in group A and 33.3% in group B (P> 0.05). The insulin resistance rate in group A was 75.0%, which was significantly higher than that in group B (38.9%, P <0.05). There was no significant difference between the three groups (P> 0.05). The levels of T, LH / FSH and HOMA-IR in group A and group B were significantly higher than those in control group (P <0.05). Conclusion: PCOS patients with hyperinsulinemia is the main cause of endometrial, insulin levels may increase the abnormal endometrial hyperplasia.