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为探讨哮喘患儿各期血清ECP、IL—5、sIL—2R和IgE水平及其相关性和临床意义,用37C凝血1h的血清,以法马西亚CAP系统检测哮喘各期和对照组ECP,以双抗体夹心ELISA法测定IL—5、sIL—2R和IgE。结果表明ECP、IgE和sIL—2R均为发作期和稳定期高于缓解期和对照组,发作期不同程度高于稳定期,IL—各期阳性率为A 51.43％、AP 56.0％、S 30.77％、N 10.0％,IL—5分别与sIL—2R和ECP成正相关,sIL—2R分别与ECP和IgE呈正相关。提示它们均参与了哮喘的发病,测定各指标可作为监测病情和指导抗炎治疗的有效方法。
In order to investigate the serum levels of ECP, IL-5, sIL-2R and IgE in children with asthma and their correlation and clinical significance, serums of 37C blood clotting for 1 hour, IL-5, sIL-2R and IgE were measured by double antibody sandwich ELISA. The results showed that both ECP, IgE and sIL-2R were higher in onset and stable than in remission and in control group. The severity of seizure was higher than that in stable phase. The positive rates of IL-1 were 51.43%, AP 56.0%, S 30.77 %, N 10.0%, IL-5 were positively correlated with sIL-2R and ECP respectively, while sIL-2R was positively correlated with ECP and IgE respectively. Suggesting that they are involved in the pathogenesis of asthma, the determination of each indicator can be used as an effective way to monitor the disease and guide anti-inflammatory treatment.