为在体内合理使用抗生素,并为在体外敏感性试验选择或设计适宜的培养基与培养条件,有必要详细了解影响抗生素生物活性的环境因素。氨基糖苷类抗生素的活性受到许多环境因素的不利影响。例如:有机培养基的成份、pH 及缺氧情况,均影响链霉素的作用。本文着重讨论无机盐(即离子环境)的影响。 In order to rationalize the use of antibiotics in the body and to select or design suitable media and culture conditions for in vitro susceptibility testing, it is necessary to learn more about the environmental factors that affect the biological activity of antibiotics. The activity of aminoglycoside antibiotics is adversely affected by many environmental factors. For example: organic medium composition, pH and hypoxia, all affect the role of streptomycin. This article focuses on the effects of inorganic salts (ie, ionic environments).