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最近十多年来,化学物质的遗传毒性作用受到公众广泛地关注,然而大量的未经致癌、致突变试验的化学物质正在被利用。目前不可能对这些化学物质全面进行致癌、致突变的动物试验,但可通过生物学短期试验来研究受试物的化学结构与其致癌性、致突变性的关系,以解决此问题,提供有用的资料。体内和体外微核试验已广泛用于检测哺乳类细胞中染色体损害,也是化学品致突变性的
In the past more than a decade, the genotoxicity of chemical substances has attracted widespread public attention. However, a large number of chemical substances that have not been tested for carcinogenicity and mutagenicity are being used. At present, it is impossible to carry out carcinogenic and mutagenic animal experiments on these chemicals in a comprehensive manner, but biological short-term experiments can be used to study the relationship between the chemical structure of the test substance and its carcinogenicity and mutagenicity to solve this problem and provide useful information. data. In vivo and in vitro micronucleus tests have been widely used to detect chromosomal damage in mammalian cells and are also mutagenic to chemicals.