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我们曾试用氯喹治疗支气管哮喘,发现有较好的临床效果。但是氯喹治疗哮喘的原理,一向认为是通过稳定细胞溶酶体膜,以及轻度抗组织胺作用。对于全身体液免疫调节,认为影响不大。 我们应用传统的大鼠被动皮肤过敏反应(PCA)在Wistar大鼠,用天花粉-铝佐剂致敏,同时灌服氯喹20mg/kg,14天后与对照血清进行72小时PCA比较,其伊文思兰渗出曲线明显右移,经析因方差分析,P<0.01。表明氯喹对IgE类抗体产生抑制。
We have tried chloroquine treatment of bronchial asthma and found to have better clinical results. However, the principle of chloroquine for the treatment of asthma has long been thought to be through stabilization of the lysosomal membrane and mild antihistamine effects. For systemic humoral immune regulation, that little effect. We used traditional rat passive cutaneous anaphylaxis (PCA) in Wistar rats to be sensitized with TCS-aluminum adjuvant while chloramphenicol 20 mg / kg, compared with control serum for 72 hours after 14 days of PCA, and Evans blue Exudation curve significantly shifted to the right, by analysis of variance analysis, P <0.01. Chloroquine showed inhibition of IgE antibodies.