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半衰期(或称半寿期,Half-life time,简称t_(1/2))是药物动力学中最基本的,很重要的一个参数。它是指药物在体内消除半量所需的时间。因绝大多数药物能测出血药浓度,故一般是指血浆药物浓度减少50％的时间而言。它反映药物在体内代谢、排泄的速率。抗癫痫药药物动力学的深入研究为临床合理用药提供了科学依据。目前抗癫痫药多达廿余种,新药还在不断被推荐于临床,了解这些药物的t_(1/2),可为临床医师制定安全有效的药物治疗方案提供依据;熟悉影响药物t_(1/2)的因素,对减少用药的盲目性、提高科学性极为必要。故本文拟以我国国家基本药物目录
Half-life (Half-life time, referred t_ (1/2)) is the most basic and important parameter in pharmacokinetics. It refers to the time it takes for the drug to eliminate half of the amount in the body. Because the vast majority of drugs can be measured plasma concentration, it is generally refers to the plasma drug concentration decreased by 50% of the time. It reflects the rate of drug metabolism in the body, excretion. Antiepileptic drug pharmacokinetics in-depth study for the clinical rational use of drugs provides a scientific basis. At present, antiepileptic drugs are up to more than 20 kinds. The new drugs are still being recommended in the clinic, and the t_ (1/2) of these drugs can provide the basis for clinicians to formulate safe and effective drug treatment programs. / 2) factors, to reduce the blindness of medication, improve science is extremely necessary. Therefore, this article will be based on the list of China’s national essential medicines