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本文用~(51)Cr标记红细胞测量肺血量(PBV)和肺血管外含水量(PEW)的方法,观察低温和缺氧对PEW的影响。 实验分为平原对照、平原寒冷、常温低氧和寒冷低氧四组。模拟海拔6000m高原48小时,舱温为10±2℃的常温缺氧织,PBV明显低于平原对照组(P<0.01);PEW虽有增多,但无显著性(P>0.05)。环境温度为-5℃的平原寒冷组PEW高于平原对照组(P<0.05)。寒冷缺氧组PEW最高,与平原对照组相比P<0.01,与平原寒冷组相比P<0.05。 实验结果表明,寒冷可使PEW增加,而寒冷和缺氧同时存在PEW增加更为明显。 寒冷缺氧使PEW增加的机制,可能与血液自外周血管向肺循环转移和肺静脉收缩等因素有关。这些因素可使缺氧后的肺动脉高压进一步升高,促进肺水肿发生。
In this paper, the effects of hypothermia and hypoxia on the PEW were observed by measuring the blood volume (PBV) and extra-pulmonary extravascular water content (PEW) with ~ (51) Cr labeled red blood cells. The experiment is divided into plain control, plain cold, room temperature hypoxia and cold hypoxia four groups. The hypoxic tissue at room temperature of 10 ± 2 ℃ was simulated 48 h after altitude 6000m, and the PBV was significantly lower than that of control group (P <0.01). PEW was not significant (P> 0.05). The PEW in plain cold group was higher than that in plain control group at ambient temperature of -5 ℃ (P <0.05). The PEW was the highest in cold and hypoxia group, P <0.01 compared with plain control group, P <0.05 compared with plain cold group. Experimental results show that cold can make PEW increased, while cold and hypoxia increased PEW more obvious. The mechanism by which cold hypoxia increases PEW may be related to the factors such as blood circulation from the peripheral blood vessels to the pulmonary circulation and pulmonary vein contraction. These factors can make pulmonary hypertension after hypoxia to further increase, promote pulmonary edema.