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目的:新剂型研制,制备蒿芩清胆颗粒。方法:应用正交实验筛选最佳工艺。结果:10倍水、6h提取挥发油;油∶-βCD为1∶6,恒温40℃搅拌包结挥发油1h;水提酸沉法提取黄芩苷;盐酸处理,乙酸乙酯提取青黛有效成分;8倍水、浸泡0.5h、煎煮3次、每次0.5h为最佳煎煮工艺;湿法制粒,稠膏∶糖粉∶糊精为1∶3.5∶1,必要时加72%乙醇为润湿剂。结论:所制颗粒剂符合药典要求。
Objective: To study the preparation of new formulation and prepare Qingqin Qingdan granule. Methods: The best technique was screened by orthogonal experiment. Results: 10 times of water, 6h extraction of essential oil; oil: -CDCD of 1: 6, constant temperature 40 ℃ stirring package oil 1h; water extraction acid precipitation extraction of baicalin; hydrochloric acid treatment, ethyl acetate extract indigo active ingredient; Water, soaked 0.5h, boiling 3 times, each 0.5h for the best boiling process; wet granulation, thick paste: sugar powder: dextrin 1: 3.5: 1, if necessary, add 72% Agent. Conclusion: The granule complies with the pharmacopoeia requirements.