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[目的]评价利普液基细胞学(LPT)在宫颈癌变诊断中的应用价值。[方法]8730例利普液基细胞学样本采用TBS分类诊断,并与组织学活检结果对照。[结果]LPT细胞学阳性者723例,总检出率8.28%,其中意义不明的不典型鳞状细胞(ASC-US)345例(占3.95%),不除外上皮内高度病变的不典型鳞状细胞(ASC-H)67例(占0.77%),低度鳞状上皮内病变(LSIL)256例(占2.93%),高度鳞状上皮内病变(HSIL)42例(占0.48%),鳞状细胞癌(SCC)11例(占0.13%),腺癌(AC)2例(占0.02%),未检到意义不明的不典型腺细胞(AGUS)。HSIL活检阳性率和准确率分别为95.24%和85.72%,ASC-US活检阳性率33.16%。[结论]LPT对宫颈病变的检测有较高的敏感性和特异性。
[Objective] To evaluate the value of limp liquid-based cytology (LPT) in the diagnosis of cervical cancer. [Method] 8730 cases of limpid liquid-based cytology samples were diagnosed by TBS classification and compared with histological biopsy results. [Results] There were 723 positive cases of LPT cytology with a total detection rate of 8.28%. Among them, 345 cases (3.95%) with atypical unclassified squamous cell carcinoma (ASC-US) Sixty-seven cases (accounting for 0.77%) of ASC-H, 256 cases (2.93%) of LSIL, 42 cases (0.48%) of high grade squamous intraepithelial lesion (HSIL) Eleven patients (0.13%) had squamous cell carcinoma (SCC) and two patients (0.02%) had adenocarcinoma (AC). No atypical glandular cells of unknown significance (AGUS) were detected. HSIL biopsy positive rate and accuracy were 95.24% and 85.72%, ASC-US biopsy positive rate of 33.16%. [Conclusion] LPT has high sensitivity and specificity for the detection of cervical lesions.