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[目的]探讨芝麻素对离体蟾蜍心脏收缩功能的影响及其机制.[方法]采用张力换能器连接BL-420系统给离体蛙心灌流模型灌流给予不同质量浓度的芝麻素溶液(0.1~0.5g/L),观察蟾蜍心肌收缩功能及心率变化.[结果]与对照组比较,芝麻素各剂量组心肌收缩力明显被抑制(P<0.05),且呈现明显的量效关系,在0.3g/L质量浓度时抑制心肌收缩力最显著;各剂量组心率均无显著变化.芝麻素(0.3g/L)的心肌抑制作用部分被阿托品拮抗.[结论]芝麻素具有负性肌力作用,作用机制可能部分通过介导M受体完成.
[Objective] To investigate the effect and mechanism of sesamin on the contractile function of isolated toad hearts. [Methods] The sera of rats were perfused with different concentrations of sesamin solution (0.1 ~ 0.5g / L). The myocardial contractile function and heart rate of Bufo bufo gargarizans were observed. [Results] Compared with the control group, the contractile force of myocardial sesamin in each dose group was significantly inhibited (P <0.05), and the dose- 0.3g / L mass concentration of myocardial contractility was the most significant; each dose group had no significant changes in heart rate. Sesamin (0.3g / L) of myocardial inhibition was antagonized in part by atropine. [Conclusion] Sesamin has negative muscle strength Role, mechanism of action may be partially mediated by M receptors.