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目的观察慢性阻塞性肺疾病急性加重期(AECOPD)患者可溶性细胞间粘附分子-1(s ICAM-1)和C反应蛋白(CRP)的指标变化,探讨其在诊治中的临床意义。方法双抗体夹心酶联免疫吸附法(ELISA)检测40例血清s ICAM-1和CRP,比较两组间的差异。结果 (1)AECOPD组血清s ICAM-1和CRP显著高于对照组,差异均有统计学意义,P<0.01。结论血清s ICAM-1和CRP可作为AECOPD诊断和判断疗效的早期指标。
Objective To observe the changes of soluble intercellular adhesion molecule-1 (s ICAM-1) and C-reactive protein (CRP) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and to explore its clinical significance. Methods 40 cases of serum s ICAM-1 and CRP were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA), and the differences between the two groups were compared. Results (1) Serum s ICAM-1 and CRP in AECOPD group were significantly higher than those in control group, with statistical significance (P <0.01). Conclusion Serum s ICAM-1 and CRP can be used as early indicators of AECOPD diagnosis and judgment of curative effect.