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使用以氟为基础的新辅助放化疗的结直肠癌的降级(DS)已接近45%。胸苷酸合成酶基因(TYMS)的多形态性已决定了有两个不同的肿瘤DS率(60%比22%)的风险组。Tan等进行了一项前瞻性、单中心的Ⅱ期临床试验,采用TYMS基因型
Colorectal cancer using fluorinated neoadjuvant chemoradiation has a degeneration (DS) of nearly 45%. Polymorphism of the thymidylate synthase gene (TYMS) has determined the risk of having two different tumor DS rates (60% vs. 22%). Tan et al. Conducted a prospective, single-center Phase II clinical trial using the TYMS genotype