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目的探讨巨细胞病毒感染与冠状动脉支架内新生内膜增生的相关性,为其临床研究提供可参考依据。方法采用回顾性研究方法收集2010年1月-2012年12月175例入住心内科冠心病患者临床资料,所有患者根据病情均给予冠状动脉支架置入术,且均于术后6个月再次行冠状动脉造影剂血管超声检查;采用酶联免疫吸附法对抗人巨细胞病毒IgG抗体进行测定,分析巨细胞病毒感染与新生内膜增生的相关性。结果 175例行冠状动脉支架置入术治疗的患者中有85例患者抗人巨细胞病毒IgG抗体阳性,阳性率48.6%;抗人巨细胞病毒IgG抗体阳性患者术前、后最小腔内直径及术后腔径增大与阴性患者比较差异无统计学意义;而阳性患者术后6个月最小腔内直径明显低于阴性患者,阳性患者术后6个月腔径减小明显低于阴性患者,差异均有统计学意义(P<0.05);同时阳性患者再狭窄21例占24.7%,阴性患者再狭窄10例占11.1%,比较差异有统计学意义(χ2=5.54,P<0.05)。结论巨细胞病毒感染与冠状动脉支架新生内膜增生存在密切的相关性,其可能增加内膜增生发生的风险,在临床工作中对于该类患者需要积极进行必要的干预措施,可能降低再狭窄的发生。
Objective To investigate the relationship between cytomegalovirus infection and neointimal hyperplasia in coronary stents, and to provide a reference for its clinical study. Methods A retrospective study was conducted to collect the clinical data of 175 patients admitted to Department of Cardiology of Cardiology from January 2010 to December 2012. All patients underwent coronary stenting according to their condition and all were reoperated 6 months after surgery Coronary artery contrast medium vascular ultrasound; enzyme-linked immunosorbent assay for anti-human cytomegalovirus IgG antibodies were measured cytomegalovirus infection and neointimal hyperplasia. Results Among the 175 patients undergoing coronary stenting, 85 patients were positive for anti-human cytomegalovirus IgG with a positive rate of 48.6%. The mean intracavitary diameter before and after anti-human cytomegalovirus IgG antibody positive and There was no significant difference between the postoperative increase of cavity diameter and the negative patients, while the positive diameter of the smallest intracavitary 6 months postoperatively was significantly lower than that of the negative patients, and the decrease of the diameter of the positive patients 6 months after operation was significantly lower than that of the negative patients (P <0.05). In the meanwhile, positive patients had restenosis in 21 cases (24.7%) and negative patients in 10 cases (11.1%). The difference was statistically significant (χ2 = 5.54, P <0.05). Conclusion Cytomegalovirus infection is closely related to neointimal hyperplasia of coronary stents, which may increase the risk of neointimal hyperplasia. In clinical work, such patients need to actively carry out necessary interventions that may reduce the risk of restenosis occur.