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目的:研究食道溃疡合剂中盐酸丁卡因的含量测定方法。方法:以pH5.8的磷酸盐缓冲液为溶媒用分光光度法进行测定。结果:盐酸丁卡因的浓度在0~1.6mg/100ml之间线性关系良好,相关系数γ=0.9999,回收率为100.08%,RSD为0.35%(n=4)。结论:本法简便、准确,重现性好,用于测定食道溃疡合剂中盐酸丁卡因的含量是可行的,尤其适用于医院制剂的快速分析。
Objective: To study the method of determination of tetracaine hydrochloride in esophageal ulcer mixture. Methods: The pH5.8 phosphate buffer as a vehicle spectrophotometric determination. Results: The linearity of tetracaine hydrochloride between 0 ~ 1.6mg / 100ml was good. The correlation coefficient γ = 0.9999, the recovery was 100.08% and the RSD was 0.35% (n = 4). Conclusion: The method is simple, accurate and reproducible. It is feasible to determine the content of tetracaine hydrochloride in the compound prescription of esophageal ulcer, especially for rapid analysis of hospital preparations.