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迷走神经刺激(vagal nerve stimulation,VNs)已被证明是治疗癫痫的有效方法,现正尝试用于包括抑郁症、焦虑症和阿尔茨海默病等临床病症的治疗。本文对近几年临床前和临床有关VNS研究的文章加以综述,简述VNS研究的主要历史,并对大量VNS的不同临床应用进行了讨论,最后探讨了VNS临床疗效的可能机制。尽管VNS作用的确切机制尚不明确,但该机制的探讨将为抑郁症的神经病理研究提供一个新的方向。
Vagal nerve stimulation (VNs) has been shown to be an effective method of treating epilepsy and is currently being tried for the treatment of clinical conditions including depression, anxiety and Alzheimer’s disease. This article summarizes the articles about VNS in preclinical and clinical researches in recent years, summarizes the main history of VNS, and discusses the different clinical applications of a large number of VNS. Finally, the possible mechanism of clinical effect of VNS is discussed. Although the exact mechanism of action of VNS is not clear, the exploration of this mechanism will provide a new direction for the study of neuropathology of depression.