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目的探讨血小板活化和溃疡性结肠炎的关系。方法对28例活动期溃疡性结肠炎、15例缓解期溃疡性结肠炎患者和正常对照组30例患者用FACSCAN型流式细胞仪检测血小板表面纤维蛋白原受体(PAC-1)和血小板α-颗粒膜糖蛋白(CD62p),用酶联免疫法检测血栓素B2(TXB2)。结果活动期UC患者血PAC-1、CD62p均较缓解期和对照组高,差异有统计学意义(P<0.05);活动期UC患者血浆TXB2较缓解期UC患者和对照组高,差异有统计学意义(P<0.01);缓解期患者PAC-1、CD62p仍高于正常对照组(P<0.05),缓解期TXB2与正常对照组无明显差异(P>0.05)。CD62p及TXB2与病情程度有关(P<0.05)。结论活动期溃疡性结肠炎体内存在血小板活化,PAC-1、CD62p是溃疡性结肠炎较特异的指标,TXB2影响血液高凝状态,抗血小板药物对溃疡性结肠炎有一定效果。
Objective To investigate the relationship between platelet activation and ulcerative colitis. Methods Twenty-eight patients with active ulcerative colitis, 15 patients with remission ulcerative colitis and 30 normal controls were examined for the expression of platelet surface fibrinogen receptor (PAC-1) and platelet α by using FACSCAN flow cytometry Granulocyte membrane glycoprotein (CD62p) was detected by enzyme-linked immunosorbent assay thromboxane B2 (TXB2). Results The plasma levels of PAC-1 and CD62p in active UC patients were significantly higher than those in remission and control groups (P <0.05). The levels of plasma TXB2 in active UC patients were higher than those in UC patients and controls (P <0.01). The levels of PAC-1 and CD62p in remission group were still higher than those in normal control group (P <0.05). There was no significant difference between TXB2 and normal control group in remission (P> 0.05). CD62p and TXB2 were related to the severity of illness (P <0.05). Conclusions Platelet activation is present in active ulcerative colitis. PAC-1 and CD62p are the specific indexes of ulcerative colitis. TXB2 affects blood hypercoagulability and antiplatelet drugs have some effects on ulcerative colitis.