论文部分内容阅读
临床上丙型肝炎病毒(HCV)非结构蛋白5A(NS5A)抑制剂联合聚乙二醇-干扰素/利巴韦林的治疗方案具有较高的持续病毒学应答获得率和耐受性,同时NS5A抑制剂的研究极大地推动了HCV治疗中不依赖干扰素治疗方案的发展。本文综述NS5A抑制剂的特性及其临床研究进展。
Clinically, the treatment regimen of hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor in combination with pegylated interferon / ribavirin has a high rate of sustained virological response and tolerability, The study of NS5A inhibitors has greatly promoted the development of HCV-independent interferon-free regimens. This article reviews the characteristics of NS5A inhibitors and their clinical progress.