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血吸虫病流行于70多个国家,有2亿多人口及大量家畜感染,造成了严重的经济损失。该病的发病率与寄生的虫数和存在于组织内的虫卵量有关,化学治疗虽然有效,但不能防止再感染,且能产生抗药性。因此,为控制血吸虫病,用血吸虫疫苗进行免疫预防很有必要。研究已表明Sm14-3-3蛋白广泛存在于寄生虫体内,主要位于雌雄生殖器官、皮层、皮下层、实质和肌组织。曼氏血吸虫至少有两种Sm14-3-3蛋白即Smal 14-3-3,Sma214-3-3,故检测其介导的免疫反应和抗血吸虫病的能力极为必要。
Schistosomiasis is endemic in more than 70 countries and has more than 200 million people and a large number of livestock infections, causing serious economic losses. The incidence of the disease is related to the number of parasitic worms and the amount of eggs present in the tissues. Chemotherapy, though effective, does not prevent re-infection and can develop resistance. Therefore, to control schistosomiasis, immunization with schistosome vaccine is necessary. Studies have shown that the Sm14-3-3 protein is widespread in the parasite, mainly in the male and female reproductive organs, cortex, subcutaneous layer, parenchyma and muscle tissue. Schistosoma mansoni At least two Sm14-3-3 proteins, Smal 14-3-3 and Sma214-3-3, are essential for the detection of their immune-mediated and anti-schistosomiasis-responsiveness.