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目的:比较沙美特罗/丙酸氟替卡松干粉剂(舒利迭)与布地奈德干粉剂吸入治疗成年支气管哮喘患者的临床效果。方法:将78例成年哮喘患者随机分为试验组和对照组各39例,试验组采用舒利迭吸入治疗,对照组采用布地奈德吸入治疗。治疗6周,观察两组短效β2-受体激动剂(沙丁胺醇喷雾剂)的使用次数、日间及夜间症状评分的变化。结果:试验组及对照组治疗后与治疗前的沙丁胺醇喷雾剂使用次数、日间及夜间症状评分都有明显变化,试验组治疗效果优于对照组。结论:与单纯糖皮质激素相比,联合糖皮质激素和长效β2-受体激动剂对哮喘的疗效更佳。
OBJECTIVE: To compare the clinical efficacy of salmeterol / fluticasone propionate dry powder (seretide) and budesonide dry powder inhalation in the treatment of adult patients with bronchial asthma. Methods: Seventy-eight adult asthmatic patients were randomly divided into experimental group and control group (n = 39). The experimental group was treated with seretide inhalation and the control group with budesonide inhalation. After 6 weeks of treatment, the changes of the number of short-acting β 2 -agonist (salbutamol spray) use, daytime and nighttime symptom scores were observed. Results: The use of albuterol spray before and after treatment in the experimental group and the control group showed significant changes in both daytime and nighttime symptom scores. The treatment effect of the experimental group was better than that of the control group. CONCLUSIONS: Combination glucocorticoids and long-acting beta 2-agonists have a better effect on asthma than simple glucocorticoids.