论文部分内容阅读
伦敦消息:法国研究人员用环孢菌素A(CyA)治疗获得性免疫缺损综合征(AIDS)的病人。他们认为,AIDS是一种自身免疫性疾病。研究人员发现,T-辅助细胞(T4细胞)的损坏不只是由于病毒的细胞病作用,因为体外培养及体内检查均发现人亲T淋巴细胞病毒-Ⅲ(HTLV-Ⅲ)只感染很少一部分的T4靶细胞。病毒感染时需要一激活的T4细胞,当病毒在T4细胞中复制时,不但释放病毒微粒,而且还能释放覆盖在未受感染的T4细胞表面的病毒蛋白质。这些被覆盖的T4细胞便成为自身免疫反应的靶子。此外,AIDS病人的淋巴结肿胀、发热等临床表现,以及免疫学和组织学的结果也提示是一种自身免疫现象。
LONDON: French researchers treated Cytosporin A (CyA) in patients with Acquired Immune Deficiency Syndrome (AIDS). They think that AIDS is an autoimmune disease. The researchers found that damage to T-helper cells (T4 cells) is not solely due to the cytopathic effect of the virus because human pro-T Lymphovirus-III (HTLV-III) infects only a small portion of T4 target cells. An activated T4 cell is required for viral infection, and when the virus replicates in T4 cells, it releases not only viral particles but also viral proteins that cover the surface of uninfected T4 cells. These covered T4 cells become targets of the autoimmune response. In addition, AIDS patients with lymph node swelling, fever and other clinical manifestations, as well as immunological and histological findings also suggest that an autoimmune phenomenon.