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德国 Justus—Liebig 大学 Preissner 等发现,受损细胞或微生物释放的 RNA 能通过激活凝血因子而启动凝血级联反应。此发现能产生新的抗血栓形成药物以及治疗脓毒病、癌症和心血管疾病的新方法。研究人员发现,在凝血接触期途径中,RNA 与因子Ⅺ和因子Ⅻ紧密结合,并增强这两种酶的激活。当RNA 用于兔子时,它引发了显著的促凝反应。在动脉血栓形成小鼠中,发现胞外 RNA 与富含纤维蛋白的血栓相关。更重要的是,在用 RNA 酶预处理的小鼠中,血栓形成明显延迟。
Preissner et al., Justus-Liebig University in Germany found that RNA released from damaged cells or microbes can activate the coagulation cascade by activating coagulation factors. This finding has led to new antithrombotic drugs and new ways to treat sepsis, cancer and cardiovascular disease. The researchers found that RNA binds tightly to factor XI and factor Ⅻ during the coagulation phase of exposure and enhances the activation of both enzymes. When RNA is used in rabbits, it triggers a significant procoagulant reaction. In arterial thrombotic mice, extracellular RNA was found to be associated with fibrin-rich thrombi. More importantly, thrombosis was significantly delayed in RNase-pretreated mice.