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Angew.Chem.Int.Ed.2014,53,4350~4354近十年来,手性金催化剂的应用越来越引起化学家们的重视,但如何高效地解决金催化的对映选择性的问题仍然是一个挑战.目前,适用于不对称金催化的配体一般是一些带有大位阻取代基的联苯类、螺环类的手性双膦配体,亚膦酰胺类配体以及一些手性卡宾配体.这些配体的具体合成步骤繁琐、难于修饰、价格昂贵的缺点.因此有必要发展一些简单,易于合成,具有多可调位点的新型手性配体.2010年,华东师范大学化学系张俊良课题组分别以
Angew.Chem.Int.Ed.2014,53,4350 ~ 4354 The application of chiral gold catalysts has attracted more and more attention from chemists in recent ten years. However, how to efficiently solve the problem of gold-catalyzed enantioselectivity Is a challenge.At present, the ligands suitable for asymmetric gold catalysis are generally biphenyls, spirocyclic chiral bisphosphine ligands, phosphonamidate ligands and some hand Carbophilic ligands.The specific synthetic steps of these ligands are cumbersome, difficult to modify, expensive shortcomings.Therefore, it is necessary to develop some simple, easy to synthesize, with a new multi-adjustable chiral ligands.In 2010, the East China Normal University Department of Chemistry Zhang Junliang task force respectively