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探讨不同功能的T细胞亚群在免疫调节中的作用,弄清编码T细胞受体的基因的组合及表达,有着十分重要的意义.作者已克隆出人T细胞受体特异性cDNA(YT_(35)),并证实其mRNA与Ig mRNA的产生极为相似,经过重排从不连续的基因序列组合成一条mRNA.其编码的蛋白质与哺乳类的IgL链很相象.作者用Northern凝胶分析法测定了白血病T淋巴细胞系、人胸腺细胞、外周血T细胞、PHA致敏的T细胞、骨髓细
It is very important to explore the role of different functions of T cell subsets in immune regulation and to understand the combination and expression of genes coding for T cell receptors.The authors have cloned human T cell receptor specific cDNA (YT_ ( 35)) and confirmed that its mRNA and Ig mRNA production are very similar, rearranged from the non-continuous sequence of genes combined into an mRNA encoding protein and mammalian IgL chain is very similar to the author with Northern gel analysis Method for the determination of leukemia T lymphocyte lines, human thymocytes, peripheral blood T cells, PHA-sensitized T cells, bone marrow fine