【摘 要】
：
目的比较血浆/血清中的EB病毒(Epstein-Barr virus,EBV)DNA检出率在健康成人和鼻咽癌患者之间的差别,评价其在鼻咽癌诊断中的意义. 方法从58例健康成人和66例未经治疗的鼻咽
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目的比较血浆/血清中的EB病毒(Epstein-Barr virus,EBV)DNA检出率在健康成人和鼻咽癌患者之间的差别,评价其在鼻咽癌诊断中的意义. 方法从58例健康成人和66例未经治疗的鼻咽癌患者获取血浆和血清标本,用巢式PCR法检测EB病毒W片段.用免疫酶标法检测IgA/VCA滴度.结果鼻咽癌患者血浆/血清EB病毒DNA检出率为84.85%,明显高于健康人(10.34%).血浆/血清EB病毒 DNA检测方法的敏感度(0.8485)高于IgA/VCA(1∶40)检测(0.8030),特异度相同(均为0.8966).血浆/血清EB病毒 DNA和IgA/VCA(1∶40)双阳性的正确率(0.8387)、阳性实验预测值(0.9792)和优势比(141.0)比单独血浆/血清EB病毒 DNA阳性(分别为0.5242,0.7333 和1.1423)或IgA/VCA 阳性者(分别为0.4839, 0.5385和1.0480)高.结论用巢式PCR方法检测血浆/血清中EB病毒DNA是诊断鼻咽癌有价值的指标之一.
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