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用ｐ５３的单克隆抗体ｐＡｂ１８０１对７３例原发乳腺癌进行免疫组化研究，并观察ｐ５３阳性表达率与肿瘤大小，组织学分极，临床分期，雌激素受体（ＥＲ）以及腋窝淋巴结转移的关系。结果表明：７３例中１７例癌细胞核Ｐ５３呈阳性表达，占２３％。ｐ５３阳性表达与肿瘤组织学分级、临床分期、ＥＲ等因素明显相关。在组织学分级Ｓ级，临床分期Ⅳ期以及ＥＲ阴性病例中，ｐ５３阳性率最高，差异显著（Ｐ＜０．０１）。而与肿瘤大小及腋窝淋巴结转移无密切关系（Ｐ＞０．０５）。对３４例病人的术后回顾性随访也表明：Ｐ５３阳性病人存活期明显低于阴性病人（Ｐ＜０．０１）。
Immunohistochemical study of 73 cases of primary breast cancer with p53 monoclonal antibody pAb1801, and observed the relationship between p53 positive expression and tumor size, histological polarization, clinical stage, estrogen receptor (ER) and axillary lymph node metastasis . The results showed that nuclear P53 expression was positive in 17 of 73 cases, accounting for 23%. The positive expression of p53 was significantly correlated with tumor histological grade, clinical stage, ER and other factors. In the histological grade S grade, clinical stage IV and ER negative cases, the positive rate of p53 was the highest, and the difference was significant (P<0.01). There was no close relationship between tumor size and axillary lymph node metastasis (P>0.05). A retrospective follow-up of 34 patients also showed that the survival time of P53-positive patients was significantly lower than that of negative patients (P<0.01).