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目的:探讨酪氨酸激酶受体RON与非小细胞性肺癌发生的可能机制。方法:应用PubMed和CHKD期刊全文数据库检索系统,以“RON、MSP和肺癌”为关键词,检索2000-01-2009-09相关文献,共检索到英文文献130篇和中文文献17篇。精选50篇,最后纳入21篇进行归纳分析。结果:国外文献对RON有较深入的分析,论及RON在乳腺、结肠、肝、肺、肾、膀胱及卵巢肿瘤中,RON呈现过度表达,发生率波动于32.8%～59%,这取决于肿瘤的类型差异。国内对MSP/RON与肺癌发生的可能机制研究明显偏少,仅为3篇。结论:RON的过度表达与肺癌的进展、转移密切相关,检测RON的异常对判断肿瘤的临床进展及转移有一定的参考价值,RON可能成为诊断治疗的新靶点。MSP/RON在肺癌发生中的机制是极其复杂的,有待进一步的阐述。
Objective: To investigate the possible mechanism of tyrosine kinase receptor RON and non-small cell lung cancer. Methods: Using PubMed and CHKD periodical full-text database retrieval system, and searching for literature about 2000-01-2009-09 with “RON, MSP and lung cancer” as keywords, 130 articles in English and 17 in Chinese were retrieved. Selected 50 articles, and finally included 21 articles for inductive analysis. Results: RON was further analyzed in foreign literature. RON was overexpressed in breast, colon, liver, lung, kidney, bladder and ovarian tumors and the incidence fluctuated between 32.8% and 59% depending on The type of tumor is different. The research on the possible mechanism of MSP / RON and lung cancer in China was obviously fewer, only 3 articles. CONCLUSIONS: The overexpression of RON is closely related to the progression and metastasis of lung cancer. Detecting the abnormality of RON has some reference value for judging the clinical progress and metastasis of tumor, and RON may become a new target of diagnosis and treatment. The mechanism of MSP / RON in the development of lung cancer is extremely complicated and needs to be further elucidated.