Natural infection of HBV DNA YMDD variant strains in a chronic hepatitis B patient before treatment

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Apatient with chronic hepatitis B was infectedwith HBV-DNA YMDD variant strains natu-rally before treatment with lamivudine. The pa-tient, female, 52 years old, has never receivedantiviral therapy. Before hysteromyomectomy,she received physical and biochemical examina-tion. Her levels of alanine aminotransferase werehigher than 140 μ/L and HBsAg was positive.She was subjected to further examination. Anti-HBe/HBV DNA was positive in the serum andYMDD variant was detected in the region of thereverse transcriptase of HBV, with methionine(M) at HBV codon 552 replaced by isoleusine(I) by direct sequence analysis of PCR products.The patient took 100mg of lamivudine orally once Apatient with chronic hepatitis B was infected with HBV-DNA YMDD variant natu-rally before treatment with lamivudine. The pa-tient, female, 52 years old, has never received antiviral therapy. Before hysteromyomectomy, she received physical and biochemical examina- tion. Her levels of alanine aminotransferase were greater than 140 μ / L and HBsAg was positive. He was subjected to further serum. HBV DNA was positive in the serum and YMDD variant was detected in the region of there is transcriptase of HBV, with methionine (M ) at HBV codon 552 replaced by isoleusine (I) by direct sequence analysis of PCR products. The patient took 100 mg of lamivudine orally once
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