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目的探讨体重指数(BMI)对血清胃蛋白酶原Ⅰ(PGⅠ)水平和PGⅠ/胃蛋白酶原Ⅱ(PGⅡ)比值的影响。方法回顾性分析2 849名表观健康体检者的临床资料,根据《中国成人超重和肥胖症预防控制指南》将BMI划分为4个级别:体重过低(<18.5 kg/m2)、体重正常(18.5~23.9 kg/m2)、超重(24.0~27.9 kg/m2)及肥胖(≥28.0 kg/m2)。比较各组间临床资料、PGⅠ水平及PGⅠ/PGⅡ比值的差异,探论BMI变化与PGⅠ、PGⅠ/PGⅡ比值的关系。结果单因素分析显示体重过低组、超重组和肥胖组血清PGⅠ水平明显低于体重正常组(P值分别为0.022、0.024和0.008),而PGⅠ/PGⅡ比值在BMI各组间差异无统计学意义(P>0.05)。调整性别、年龄、血脂等混杂变量后,PGⅠ与BMI呈明显负相关(β=-1.232,P<0.001)。二分类Logistic回归分析显示肥胖是低PGⅠ水平(<70μg/L)的相对独立危险因素之一(OR=1.682,P=0.001)。结论福建沿海地区部分人群血清低PGⅠ水平可能与肥胖有关。
Objective To investigate the effect of body mass index (BMI) on the serum level of PGI and the ratio of PGⅠ / PGⅡ. Methods The clinical data of 2 849 healthy volunteers were retrospectively analyzed. The BMI was divided into four grades according to the Guide to Prevention and Control of Overweight and Obesity in Adults in China: underweight (<18.5 kg / m2), normal weight (18.5 ~ 23.9 kg / m2), overweight (24.0 ~ 27.9 kg / m2) and obesity (≥28.0 kg / m2). The differences of the clinical data, the level of PG Ⅰ and the ratio of PG Ⅰ / PG Ⅱ between the two groups were compared. The relationship between the changes of BMI and the ratio of PG Ⅰ and PG Ⅰ / PG Ⅱ was explored. Results Univariate analysis showed that serum PGⅠ levels in overweight group, overweight group and obesity group were significantly lower than those in normal weight group (P = 0.022,0.024 and 0.008, respectively), while there was no significant difference in PGⅠ / PGⅡ between BMI groups Significance (P> 0.05). After adjusting gender, age, blood lipid and other miscellaneous variables, PGI was negatively correlated with BMI (β = -1.232, P <0.001). Logistic regression analysis showed that obesity was one of the independent risk factors of low PGI level (<70μg / L) (OR = 1.682, P = 0.001). Conclusions Serum low PG Ⅰ level in some people in coastal area of Fujian may be related to obesity.