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早已发现肿瘤可长期处于静止、潜伏、无明显生长的状态———肿瘤休眠。随着对肿瘤休眠本质和机制研究的深入,近年来肿瘤休眠疗法及其临床应用已受到关注:低剂量连续化疗;抗血管生成疗法;单抗、瘤苗等免疫疗法及其综合应用,可能使肿瘤/转移灶长期处于休眠状态,达到延长寿命、改善生活质量之效,这对进展性、再发癌,尤其是高龄患者不失为可行、可以耐受、可能有效的新疗法。
Tumor has long been found to be at rest, latent, no obvious growth state --- tumor dormancy. With the deepening of research on the nature and mechanism of tumor dormancy, in recent years, there have been concerns about tumor dormancy therapy and its clinical application: low-dose continuous chemotherapy, antiangiogenic therapy, immunotherapy with monoclonal antibody and tumor vaccine, and its comprehensive application, Long-term tumor / metastasis dormancy, to extend the life expectancy, improve the quality of life of the effect, which progress, recurrence of cancer, especially in elderly patients is feasible, tolerable, and may be effective new therapies.