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目的:探讨多功能蛋白聚糖Versican与TNF-α在胆囊癌组织中的表达及意义。方法:应用免疫组化方法检测并比较Versican与TNF-α在62例胆囊癌组织(肿瘤组)、30例胆囊结石伴慢性炎症的胆囊组织(炎症组)、20例正常胆囊组织(正常组)中的表达,分析两者与胆囊癌患者临床病理特征及预后的关系。结果:Versican与TNF-α在正常组、炎症组、肿瘤组中阳性表达率均呈依次逐渐增高,差异均有统计学意义(均P<0.05);Versican与TNF-α在胆囊癌组织中的表达呈正相关(r=0.501,P<0.05)。Versican与TNF-α的表达均与患者TNM分期、淋巴结转移有关,且Versican还与胆囊癌分化程度有关(均P<0.05)。生存分析显示,Versican与TNF-α阳性表达患者生存率均明显低于各自阴性患者(χ2=5.240、5.493,均P<0.05),但两者均阳性患者的生存率与两者单一阳性的患者差异无统计学意义(均P>0.05)。结论:Versican与TNF-α可能在胆囊癌的发生发展过程中起重要作用,且Versican与TNF-α的阳性表达为胆囊癌的不良预后因素。
Objective: To investigate the expression and significance of versican and TNF-α in gallbladder carcinoma. Methods: The expressions of Versican and TNF-α in 62 gallbladder carcinomas (tumor group), 30 gallbladder stones with chronic inflammation (inflammation group) and 20 normal gallbladder tissues (normal group) were detected by immunohistochemistry. The relationship between the two and clinicopathological features and prognosis of gallbladder carcinoma was analyzed. Results: The positive expression rates of Versican and TNF-α in normal group, inflammation group and tumor group were gradually increased, the difference was statistically significant (all P <0.05); Versican and TNF-α in gallbladder carcinoma The expression was positively correlated (r = 0.501, P <0.05). The expressions of Versican and TNF-α were related to TNM stage and lymph node metastasis, and Versican was also related to the differentiation degree of gallbladder carcinoma (all P <0.05). Survival analysis showed that the survival rates of Versican and TNF-αpositive patients were significantly lower than those of negative patients (χ2 = 5.240,5.493, all P <0.05), but the survival rates of both patients with positive expression of both Versican and TNF- The difference was not statistically significant (all P> 0.05). Conclusion: Versican and TNF-α may play an important role in the carcinogenesis and progression of gallbladder carcinomas, and the positive expression of Versican and TNF-α is a poor prognostic factor in gallbladder carcinomas.