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目的检测慢性乙型肝炎 ,肝炎性肝硬变和原发性肝癌患者血清一氧化氮浓度 ,并探讨其临床意义。方法采用硝酸还原酶法分别检测三类肝病各 30例患者血清一氧化氮浓度 ,并与 2 0例正常献血员进行对照。结果三类肝病患者血清一氧化氮浓度均显著高于正常对照 (P<0 .0 5 ) ,以原发性肝癌患者最高 ;肝硬变失代偿期血清一氧化氮水平显著高于代偿期水平 (P<0 .0 5 ) ;与成活组相比 ,原发性肝癌术后恶化组术前一氧化氮水平显著升高 (P<0 .0 5 )。结论一氧化氮参与慢性肝病、原发性肝癌发病机制 ,长期高水平的一氧化氮对机体损害作用可能大于保护作用
Objective To detect serum nitric oxide concentration in patients with chronic hepatitis B, hepatitis cirrhosis and primary liver cancer and to explore its clinical significance. Methods Nitric acid reductase method was used to detect serum nitric oxide levels in 30 patients with three types of liver diseases and compared with 20 normal blood donors. Results The levels of serum nitric oxide in three kinds of liver disease patients were significantly higher than those in normal controls (P <0.05), with the highest in patients with primary liver cancer; the levels of serum nitric oxide in patients with decompensated cirrhosis were significantly higher than those in decompensated patients (P <0.05). Compared with the survival group, the preoperative nitric oxide level in patients with postoperative deterioration of primary liver cancer was significantly increased (P <0.05). Conclusions Nitric oxide is involved in the pathogenesis of chronic liver disease and primary liver cancer, and the long-term high level of nitric oxide may be more harmful to the body than the protective effect