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目的探讨热毒宁注射液对儿童呼吸道合胞病毒肺炎(RSVP)痰热闭肺证的中西医症状积分、症状体征缓解时间及安全性的影响。方法 112例RSVP痰热闭肺证住院患儿均来自2008—2010年洛阳市机车医院及洛阳市第一中医院儿科住院部。随机分为两组,均给予利巴韦林注射液静滴,治疗组(58例)同时给予热毒宁注射液静滴,对照组(54例)给予盐酸氨溴索葡萄糖注射液静滴。观察两组治疗前后中西医症状积分变化,主要症状及体征的缓解时间、住院时间及不良反应。结果治疗后两组中西医症状积分及总积分均明显下降,治疗组下降更为显著(P<0.05或P<0.01)。治疗组西医症状改善率为82.31%,对照组为65.52%(P<0.05);治疗组中医症状改善率为77.80%,对照组为48.24%(P<0.01)。治疗组总有效率为93.10%,对照组为81.48%(P<0.05)。治疗组主要症状、体征完全缓解时间及出院时间均较对照组明显缩短(P<0.05或P<0.01)。结论热毒宁注射液佐治儿童RSVP痰热闭肺证起效快且疗效肯定、持续。
Objective To investigate the effect of Revedunin injection on symptom and symptom relief time and safety of children with respiratory syncytial virus pneumonia (RSVP). Methods One hundred and twelve patients with RSVP phlegm-heat and lung-closure syndrome were from Department of Pediatrics, Luoyang Locomotive Hospital and Luoyang No.1 Hospital of Traditional Chinese Medicine, 2008-2010. The patients in the treatment group (58 cases) received intravenous injection of Requenizu injection, while the control group (54 cases) received intravenous infusion of ambroxol hydrochloride injection. Before and after treatment, the scores of TCM symptom and symptom were observed. The main symptoms and signs of relief, hospital stay and adverse reactions were observed. Results After treatment, the symptom score and the total score of both TCM and WM decreased significantly in both groups, the treatment group decreased more significantly (P <0.05 or P <0.01). The improvement rate of Western medicine was 82.31% in the treatment group and 65.52% in the control group (P <0.05). The symptom improvement rate was 77.80% in the treatment group and 48.24% in the control group (P <0.01). The total effective rate was 93.10% in the treatment group and 81.48% in the control group (P <0.05). The main symptoms of the treatment group, signs of complete remission and discharge time were significantly shorter than the control group (P <0.05 or P <0.01). Conclusion Reveduning injection RSVP phlegm heat and lung closure syndrome in children with rapid onset and efficacy of positive, sustained.