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目的探讨应用淋巴细胞免疫治疗方法对反复性自然流产患者临床治疗效果,并分析其与妊振结局的关系。方法对109例BA抗体阴性的反复性自然流产患者注射器配偶的淋巴细胞进行免疫治疗,观察治疗后BA抗体的阳转情况及与妊振结局的关系,分析流产次数,年龄与妊娠结局的关系。结果患者接受淋巴细胞免疫治疗3次后,BA出现阳转的患者73例(67%),免疫治疗6次后BA出现阳转的患者97例(98.2%)。97例BA阳转患者妊娠成功率为91.8%(89/97),12例患者BA仍阴性,仅5例患者妊娠成功,妊娠成功率为41.7%(5/12),二者相比,差异有统计学意义(P<0.05);流产次数≤2次患者治疗后妊振成功率为91%,2<流产次数≤5患者妊娠成功率为78.6%,二者相比,差异有统计学意义(P<0.05);患者年龄≤35岁时妊振成功率要明显高于年龄>35岁的患者(P<0.05)。结论淋巴细胞免疫治疗能提高反复性自然流产患者BA的阳转率,提高反复性自然流产患者再次妊振成功率,患者应该在流产2次后尽早确诊治疗,以进一步提高妊娠成功率。
Objective To investigate the clinical effect of lymphocyte immunotherapy on patients with recurrent spontaneous abortion and analyze its relationship with pregnancy outcome. Methods 109 cases of BA antibody-negative patients with recurrent spontaneous abortion syringe spleen lymphocytes immunotherapy, treatment of BA positive after treatment and the relationship between the outcome of pregnancy and pregnancy, the number of abortion, age and pregnancy outcomes. Results After receiving lymphocyte immunotherapy three times, 73 cases (67%) were positive with BA and 97 cases (98.2%) with positive BA after 6 immunotherapy. The success rate of pregnancy in 97 patients with positive BA was 91.8% (89/97). BA was still negative in 12 patients. Pregnancy was successful in 5 patients (41.7%, 5/12). The difference was significant (P <0.05). The success rate of pregnancy induced by spontaneous abortion after treatment was 91%, and the pregnancy success rate was 78.6% for 2 patients with abortion ≤5.The difference was statistically significant (P <0.05). The success rate of gestational vibration in patients ≤ 35 years old was significantly higher than that in patients> 35 years old (P <0.05). Conclusions Lymphocyte immunotherapy can increase the positive rate of BA in patients with recurrent spontaneous abortion and improve the success rate of recurrent pregnancy-induced abortion in patients with recurrent spontaneous abortion. Patients should be diagnosed and treated as soon as possible after the second abortion to further improve the success rate of pregnancy.