细胞内钙内环境的异常与缺血性脑病的病理生理密切相关,钙拮抗剂阻止钙离子流入细胞,动物模型显示它具有减轻缺血性脑病的作用。8个国家的24所医院参加本项临床研究,由匹兹堡大学国际复苏研究中心组织协调。对象为520例心脏停搏复苏后昏迷的病人,平均年龄62(12～95)岁,62%为男性, Abnormal intracellular calcium environment is closely related to the pathophysiology of ischemic encephalopathy. Calcium antagonists prevent the influx of calcium ions into the cells. Animal models show that it has the effect of reducing ischemic encephalopathy. Twenty-four hospitals in eight countries participated in this clinical study and were coordinated by the International Recovery Research Center at the University of Pittsburgh. The subjects were 520 coma patients after cardioversion, with an average age of 62 (12-95) years, 62% of men,