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目的探讨精子形态对常规体外受精(IVF)及单精子卵胞浆内注射(ICSI)周期的受精率、卵裂率、优胚率及妊娠率的影响。方法将2011年6月至2014年6月在我院行IVF/ICSI治疗的周期根据精子形态进行分组:IVF周期分为A组(正常精子形态<2%),B组(2%≤正常精子形态<4%),C组(正常精子形态≥4%);ICSI周期分为D组(正常精子形态<2%),E组(2%≤正常精子形态<4%),F组(正常精子形态≥4%),分别比较各组间受精率、卵裂率、优胚率及妊娠率的差异。结果 IVF周期中C组受精率显著高于B组和A组,差异具统计学意义(P<0.05),卵裂率、优胚率及妊娠率在A、B、C组之间则无显著性差异(P>0.05);ICSI周期中D组、E组、F组受精率、卵裂率、优胚率及妊娠率无显著性差异(P>0.05)。结论畸形精子症会影响IVF周期的受精率,对ICSI周期的受精率无显著性影响。
Objective To investigate the effects of sperm morphology on fertilization rate, cleavage rate, excellent embryo rate and pregnancy rate in routine in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. Methods The cycles of IVF / ICSI treatment in our hospital from June 2011 to June 2014 were grouped according to the sperm morphology. The IVF cycles were divided into group A (normal sperm morphology <2%), group B (2% ≤ normal sperm Group C (normal sperm morphology≥4%); ICSI cycle was divided into group D (normal sperm morphology <2%), group E (2% ≤ normal sperm morphology <4%), group F Sperm morphology ≥ 4%) were compared between groups fertilization rate, cleavage rate, excellent embryo rate and pregnancy rate differences. Results The IVF cycle C group fertilization rate was significantly higher than the B group and A group, the difference was statistically significant (P <0.05), cleavage rate, excellent embryo rate and pregnancy rate in the A, B, C group was no significant (P> 0.05). There was no significant difference in fertilization rate, cleavage rate, excellent embryo rate and pregnancy rate between D group, E group and F group in ICSI cycle (P> 0.05). Conclusion Deformity sperm disorder will affect the IVF cycle fertilization rate, ICSI cycle fertilization rate had no significant effect.