Anitshkow首先提出脂质特别是脂固醇与动脉硬化的关系,逐渐形成今天的动脉硬化的脂质沉积学说。其根据则有动物试验及流行病学以及生理、生化或病理学各方面的研究成果,至今仍为大多数学者所相信。另方面,也有血液中的脂质(脂蛋白)虽然很高也不引起动脉硬化的情况。例如,静脉注射表面活性剂Triton WR1,339时,尽管血中脂质水平升高但与具有同样血清脂质水平的家兔相比,却可看到动脉硬化受到控制的现象。最近Kramsch等报告给猴各种钙拮抗剂如镧、EHDP、AHDP、APDP等,尽管引起持续性高脂血症却几乎不出现动脉硬化的病变。这些实验显示出血液中存在的脂质特别是低密度脂蛋白(LDL)即使浓度很高,只要对于它与血管壁之间的相 Anitshkow first proposed the relationship between lipid, especially, steroids and atherosclerosis, and gradually formed the theory of lipid deposition in today’s atherosclerosis. Based on animal experiments and epidemiological and physiological, biochemical or pathological aspects of the research results, is still believed by most scholars. On the other hand, there is also a case where the blood lipid (lipoprotein) is high and does not cause arteriosclerosis. For example, intravenous injection of the surfactant Triton WR1,339 shows that atherosclerosis is under control despite increased blood lipid levels compared to rabbits with the same serum lipid levels. Recently Kramsch et al reported to monkey various calcium antagonists such as lanthanum, EHDP, AHDP, APDP and so on, although the incidence of persistent hyperlipidemia but almost no atherosclerosis lesions. These experiments show that even at very high concentrations of lipids, especially low-density lipoproteins (LDLs), present in the blood,