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目的对初治涂阳肺结核治疗方案进行探讨,为有效控制结核疫情提供可靠的对策和措施。方法对初治涂阳肺结核病人采用2HREZ(S)/4HR和2H3R3E3Z3(S3)/4H3R3两种化疗方案治疗,并对疗效进行分析。结果痰菌转阴率在疗程2个月末时分别为88.4%和86.4%,6个月末时分别为91.9%和88.1%,两组X线胸片明显改善,其病灶吸收有效率分别为97.1%和96.2%,不良反应发生率为23.8%和23.2%。两组痰菌阴转率、X线胸片改变情况、药物不良反应发生率的差异均无统计学意义(P>0.05)。结论全程间歇短程化疗方案与全程每日短程化疗方案有同样的化疗效果,且简便、经济,便于患者接受和督导管理。
Objective To explore the treatment plan of smear-positive pulmonary tuberculosis in early stage and provide reliable countermeasures and measures for effectively controlling tuberculosis outbreak. Methods Two kinds of chemotherapy regimens of 2HREZ (S) / 4HR and 2H3R3E3Z3 (S3) / 4H3R3 were used to treat smear-positive pulmonary tuberculosis patients. The curative effect was analyzed. Results The negative conversion rate of sputum bacterium was 88.4% and 86.4% at the end of the two months of treatment and 91.9% and 88.1% respectively at the end of 6 months. The X-ray films of both groups were significantly improved, and the effective rates of lesion absorption were 97.1% And 96.2%, the incidence of adverse reactions were 23.8% and 23.2%. Two groups of sputum negative conversion rate, X-ray changes, the incidence of adverse drug reactions were no significant difference (P> 0.05). Conclusion The whole-course intermittent short-course chemotherapy regimen has the same chemotherapeutic effect as the full-scale daily short-course chemotherapy regimen, and is simple, economical and convenient for patient acceptance and supervision.