消炎痛为非甾体消炎药物,于1963年合成,用于临床。始初用于消炎、镇痛、抗风湿。1971年Vane 阐明此类药物的作用机制生要为抑制前列腺素(以下简称 PG)的生物合成。随着研究的不断深入,消炎痛的临床应用日趋广泛,成为较有前途的药物。现临床已用于肾小球肾炎、动脉导管未闭、Batter 氏综合征、直立性低血压、眼科疾患、痛经、偏头痛、胆绞痛,还可用于各种肿瘤发热、非特异性低热以及防治早产。然而,该药在常 Indomethacin is a non-steroidal anti-inflammatory drug, synthesized in 1963 for clinical use. Initially used for anti-inflammatory, analgesic, anti-rheumatic. In 1971, Vane clarified that the mechanism of action of such drugs is to inhibit the biosynthesis of prostaglandins (hereinafter referred to as PG). With the deepening of the research, the clinical application of indomethacin is becoming more and more extensive, becoming a more promising drug. Has been used clinically for glomerular nephritis, patent ductus arteriosus, Batter’s syndrome, orthostatic hypotension, ophthalmology, dysmenorrhea, migraine, biliary colic, but also for a variety of tumor fever, non-specific low fever and prevention and treatment Premature delivery. However, the drug is often