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目的研究健脾理气抑瘤方联合细胞因子诱导的杀伤细胞(CIK)治疗对晚期肝细胞癌(HCC)患者免疫功能和生活质量的影响。方法将60例晚期HCC患者根据是否愿意服用健脾理气抑瘤方分为观察组和对照组,观察组接受健脾理气抑瘤方联合CIK治疗治疗,对照组接受辨证中药联合CIK治疗。通过T细胞亚群及EORTC QLQ-C30评分量表,观察两组治疗前后免疫功能及生活质量的变化。结果观察组治疗后外周血T细胞亚群中的CD3~+、CD4~+、CD8~+、NK~+细胞比例较治疗前升高,对照组的CD3~+、CD4~+、NK~+细胞比例较治疗前升高,两组的CD3+差值比较差异有统计学意义(P<0.05)。观察组治疗后躯体功能、情感功能、总健康评分较前增加,疲倦、恶心呕吐、气短、食欲、便秘、腹泻条目评分较前下降;对照组治疗后躯体功能评分较前增加,疲倦条目评分较前下降;两组的总健康和疲倦差值比较差异有统计学意义(P<0.05)。治疗期间两组患者未见严重不良反应。结论中药联合CIK治疗能改善晚期HCC患者的免疫功能和生活质量;健脾理气抑瘤方联合CIK治疗效果更优。
Objective To investigate the effect of Jianpi Liqi Yiliu decoction combined with cytokine-induced killer (CIK) treatment on immune function and quality of life in patients with advanced hepatocellular carcinoma (HCC). Methods Sixty patients with advanced HCC were divided into the observation group and the control group according to their willingness to take Jianpi Liqi Yiliu Decoction. The observation group received Jianpi Liqi Yiliu Decoction combined with CIK treatment, and the control group received TCM combined with CIK. T cell subsets and EORTC QLQ-C30 scoring scale were used to observe the changes of immune function and quality of life before and after treatment. Results The proportion of CD3 ~ +, CD4 ~ +, CD8 ~ + and NK ~ + cells in peripheral T lymphocyte subsets increased in the observation group compared with that before treatment. The levels of CD3 +, CD4 +, NK + The proportion of cells increased compared with that before treatment. There was significant difference in CD3 + between the two groups (P <0.05). Body function, emotional function and total health score of the observation group increased compared with the previous ones after treatment. The scores of fatigue, nausea, vomiting, shortness of breath, appetite, constipation and diarrhea decreased compared with those before. The body function scores of the control group increased after treatment, Before falling; There was significant difference between the two groups in total health and tiredness (P <0.05). Two groups of patients during treatment no serious adverse reactions. Conclusion Chinese medicine combined with CIK treatment can improve the immune function and quality of life in patients with advanced HCC. Jianpi Liqi Yiliu decoction combined with CIK is more effective.