脂肪酶催化的新反应—酯氨解反应 (羧酸可以在脂肪酶作用下形成酯 ,然后在同一酶作用下进行酯氨解反应 ) ,不仅是合成手性酰胺的一个非常有用的方法 ,而且也是手性羧酸及手性醇动力学拆分的有效途径。通过比较脂肪酶催化几种外消旋酯水解、转酯及氨解反应 ,得出脂肪酶催化酯氨解反应在制备光学纯化合物中将有广阔的应用前景这一结论。 Lipase-catalyzed new reactions - Ester ammonolysis (carboxylic acids can form esters under the action of lipases and then undergo esometamolysis with the same enzymes) is not only a very useful method for the synthesis of chiral amides, but also It is also an effective way to resolve chiral carboxylic acid and chiral alcohol kinetics. By comparing the hydrolysis, transesterification and ammonolysis reactions of several racemic esters catalyzed by lipase, the conclusion that lipase catalyzes ester hydrolysis reaction will have broad application prospects in the preparation of optically pure compounds.