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目的 :为了探讨 P1 6蛋白表达与喉癌颈淋巴结转移及与癌组织恶性度的关系。方法 :用免疫组化 SP法对 82例声门上型喉癌的原发灶、癌旁组织及颈淋巴结进行了 P1 6蛋白表达的检测。结果 :喉癌原发灶中 P1 6蛋白表达阳性率 5 4.9% ;其中无颈淋巴结转移组阳性率为 6 8.3% ;有颈淋巴结转移组的阳性率 41 .5 % ,差异有显著性意义 (P <0 .0 5 )。低度恶性组原发灶中 P1 6蛋白表达阳性率 6 2 .2 % ;高度恶性组原发灶中 P1 6蛋白表达阳性率 41 .7% ,差异显著 (P <0 .0 5 )。高度恶性及原发灶 P1 6蛋白表达阴性组颈淋巴结转移率 81 .0 % ;低度恶性原发灶 P1 6蛋白表达阳性组颈淋巴结转移率 33.3% ,转移率间也有显著性差异 (P <0 .0 0 1 )。P1 6基因及其蛋白产物与喉癌的恶性度及颈淋巴结转移有相关倾向。结论 :临床检测 P1 6蛋白表达对判定喉癌组织的恶性度及推测颈淋巴结潜在性转移有一定参考价值
Objective: To investigate the relationship between the expression of P1 6 protein and cervical lymph node metastasis of laryngeal carcinoma and its relationship with the malignant degree of cancer tissue. Methods: The expression of P1 6 in 82 cases of supraglottic laryngeal carcinoma was detected by immunohistochemical SP method. Results: The positive rate of P1 6 protein in primary laryngeal carcinoma was 5 4.9%. The positive rate of cervical lymph node metastasis was 6 8.3%. The positive rate of cervical lymph node metastasis was 41.5%. The difference was significant ( P <0. 05). The positive rate of P1 6 protein in primary malignant lesions was 62.2%. The positive rate of P1 6 protein in primary lesions in high grade lesions was 41.7% (P <0.05). Highly metastatic cervical lymph node metastasis was found in 81.0% of patients with highly malignant and primary lesions of P1 6 protein negative expression. The rate of cervical lymph node metastasis was 33.3% in low grade malignant primary lesions of P1 6 protein (P < 0 .0 0 1). The P1 6 gene and its protein products are associated with the malignancy of the laryngeal carcinoma and cervical lymph node metastasis. Conclusion: The clinical detection of P1 6 protein has some reference value for judging the malignancy of laryngeal carcinoma and estimating the potential metastasis of cervical lymph node