论文部分内容阅读
目的 研究不同时期的肥胖与子宫内膜癌发生之间的关系。方法 采用全人群病例对照研究 ,调查 1997年 1月至 2 0 0 0年 6月确诊的上海市区 4 97例 30～ 6 9岁子宫内膜癌病例和 4 97名对照的发育史 ,并进行身体测量。结果 青少年时期的身高和体重与子宫内膜癌未见显著性关联 ;除2 0岁左右外 ,成年各阶段的体重指数 (BMI)均与子宫内膜癌的发生有关 ,体重增加 >7.5kg显著增加子宫内膜癌的危险 ,但体重增加比例为 15 %以上只在 4 0～ 5 0岁年龄段有显著意义。 2 0～ 30岁的体重减轻对子宫内膜癌有保护作用。体重、BMI、腰围臀围比 (WHR)的测量值大均是子宫内膜癌发生的独立危险因素 ,而身高、坐高身高比与子宫内膜癌的发生无关。结论 青少年时期肥胖与子宫内膜癌的发生无显著联系 ,而成年时期的肥胖程度和体脂的分布均是独立危险因素。 30岁前后体重变化对子宫内膜癌的发生具有不同的影响。
Objective To study the relationship between obesity and endometrial cancer in different periods. Methods A population-based case-control study was conducted to investigate the developmental history of 4 97 cases of endometrial cancer from 30 to 69 years and 4 97 controls diagnosed in Shanghai from January 1997 to June 2000 and carried out Body measurement. Results No significant correlation was found between height and body weight of adolescent and endometrial cancer. The body mass index (BMI) of all stages except adulthood was associated with the occurrence of endometrial cancer except body weight gain> 7.5kg Increase the risk of endometrial cancer, but the weight gain of more than 15% only in 40 ~ 50 years of age have significant significance. Weight loss of 20 to 30 years of age has a protective effect on endometrial cancer. Body weight, BMI and WHR measurements were all independent risk factors for endometrial cancer. However, the height-height-height ratio had no relation with the occurrence of endometrial cancer. Conclusion There is no significant correlation between obesity and the occurrence of endometrial cancer in adolescence. However, obesity and body fat distribution in adulthood are all independent risk factors. Changes in body weight before and after 30 years have different effects on the occurrence of endometrial cancer.