论文部分内容阅读
目的:探讨女性人群瘦素(leptin)与骨转换生化指标血清骨钙素(sOC)、血I型胶原氨基末端肽(sNTX)和尿I型胶原氨基末端肽(uNTX)及骨密度(BMD)之间的关系。方法:用ELISA测定leptin、sOC、sNTX和uN-TX,用DXA仪测定腰椎(AP)L1-L4、股骨颈(FN)的BMD。结果:(1)直线相关分析显示,血清leptin与年龄、体重和体重指数呈正相关(P<0.001),血清leptin随年龄和体重指数的变化均以三次模型拟合最优。(2)血清leptin与sOC和sNTX相关无显著性,与uNTX/Cr呈负相关(r值为-0.093,P<0.05),但用年龄和体重指数校正后,其与uNTX/Cr的相关无显著性。(3)血清Leptin与腰椎正位和股骨颈BMD相关均无显著性,年龄和体重指数校正后sOC、sNTX和uNTX/Cr仍与各部位BMD呈负相关(P<0.001)。结论:leptin虽然参与骨重建的调节,但血清leptin并不是骨代谢和骨密度的直接影响因素。
OBJECTIVE: To investigate the relationship between leptin, biochemical markers of bone turnover (sOC), sNTX, uNTX and BMD in female population. The relationship between. Methods: Leptin, sOC, sNTX and uN-TX were measured by ELISA. BMD of lumbar vertebra (AP) L1-L4 and femoral neck (FN) were measured by DXA. Results: (1) The linear correlation analysis showed that serum leptin was positively correlated with age, body weight and body mass index (P <0.001). The leptin level was best fitted by three times model with age and body mass index. (2) Serum leptin was not significantly correlated with sOC and sNTX but negatively correlated with uNTX / Cr (r = -0.093, P <0.05), but correlated with uNTX / Cr after adjustment for age and body mass index Significance. (3) There was no significant correlation between serum leptin and lumbar spine and femoral neck BMD. Corrections of sOC, sNTX and uNTX / Cr after age and body mass index were still negatively correlated with BMD of each site (P <0.001). Conclusion: Although leptin is involved in the regulation of bone remodeling, serum leptin is not a direct factor affecting bone metabolism and bone mineral density.