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ＢＡＬＢ／ｃ小鼠经可溶性日本血吸虫成虫抗原（ＳＷＡＰ）或／和可溶性蚯蚓抗原（ＳＥＷＰ）免疫后，观察、计数其胸腺Ｔ细胞总数、活性Ｔ细胞、Ｌ３Ｔ４细胞以及Ｌｙｔ２细胞。结果显示，ＳＷＡＰ免疫组Ｌ３Ｔ４细胞明显增加（Ｐ＜０．０５）；ＳＥＷＰ免疫组４个指标则均无明显变化（Ｐ＞０．０５）；ＳＷＡＰ与ＳＥＷＰ混合制剂免疫组Ｔ细胞总数、活性Ｔ细胞以及Ｌ３Ｔ４细胞均显增加（Ｐ＜０．０５）。相关分析表明：ＣＤ＋４Ｔ细胞（即Ｌ３Ｔ４细胞）在ＳＷＡＰ所诱导的保护性免疫力中可能起重要作用，而ＳＥＷＰ存在细胞免疫以外的其它可能保护性免疫机制，但ＳＥＷＰ与ＳＷＡＰ有明显的协同作用
BALB / c mice were immunized with soluble Schistosoma japonicum adult worm antigen (SWAP) and / or soluble earthworm antigen (SEWP), and the total number of thymus T cells, activated T cells, L3T4 cells and Lyt2 cells were observed. The results showed that the number of L3T4 cells in SWAP immunized group was significantly increased (P <0.05), while there was no significant change in SEWP immunized group (P> 0.05) Cells and L3T4 cells were significantly increased (P <0.05). Correlation analysis showed that CD + 4T cells (ie, L3T4 cells) may play an important role in protective immunity induced by SWAP, while SEWP may have other protective immune mechanisms besides cellular immunity. However, SEWP has obvious synergistic effect with SWAP