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用锂钙硼(LCB)玻璃在磷酸盐溶液中的原位转化反应制备多孔羟基磷灰石(HA)微球,表征微球的物相组成、孔结构和形貌,以溶菌酶为药物模型研究了药物的缓释性能。结果表明,所制备的HA微球具有较好的孔结构。当溶菌酶溶液的浓度较低时,HA微球将溶菌酶吸附在微球的外表面;当浓度较高时,更多的溶菌酶扩散进入HA微球的微孔中,使缓释效果明显改善。当溶菌酶溶液的初始浓度为1.0 mg/ml时,载药HA微球的释药周期可达800 h以上。
Porous hydroxyapatite (HA) microspheres were prepared by in situ transformation reaction of lithium-calcium-boron (LCB) glass in phosphate solution to characterize the phase composition, pore structure and morphology of the microspheres. Lysozyme was used as the drug model The sustained-release properties of the drug were studied. The results show that the prepared HA microspheres have good pore structure. When the concentration of lysozyme solution is low, the HA microspheres adsorb the lysozyme on the outer surface of the microspheres; when the concentration is higher, more lysozyme diffuses into the micropores of the HA microspheres and the sustained release effect is obvious improve. When the initial concentration of lysozyme solution was 1.0 mg / ml, drug-loaded HA microspheres release cycle up to 800 h or more.