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目的 :评价高同型半胱氨酸 (Hcy)血症中的氧化损伤机制。方法 :所有入选者均接受冠状动脉造影明确有无冠心病 ,并通过高压液相色谱仪测量血浆Hcy浓度。以高于 15 μmol/L为标准 ,分为高Hcy血症组〔(病例组 ) 4 9例〕与对照组 (70例 )。所有入选者均测量血浆超氧化物歧化酶 (SOD)和丙二醛 (MDA)浓度。结果 :高Hcy血症组的血浆MDA水平升高 ,与对照组比较差异有显著性意义 (P <0 .0 5 ) ,高Hcy血症组血浆SOD水平较对照组增高 ,但差异无显著性意义 (P >0 .0 5 )。结论 :氧化损伤是Hcy的毒性作用机制之一
Objective: To evaluate the mechanism of oxidative damage in hyperhomocysteinemia. METHODS: All enrolled patients underwent coronary angiography for the presence or absence of coronary heart disease and plasma Hcy concentrations were measured by high pressure liquid chromatography. Higher than 15 μmol / L as the standard, divided into high Hcy blood group 〔(case group) 49 cases〕 and the control group (70 cases). All participants measured plasma levels of superoxide dismutase (SOD) and malondialdehyde (MDA). Results: The level of plasma MDA in hyperhomocysteinemia group was significantly higher than that in control group (P <0.05). The level of plasma SOD in hyperhomocysteinemia group was higher than that in control group, but there was no significant difference Significance (P> 0.05). Conclusion: Oxidative damage is one of the toxic mechanisms of Hcy