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目的:探讨高原地区围产期妇女所处环境,服用药物,接触致畸因素,对出生缺陷发生的影响。方法:采用回顾性分析青海省2000年—2007年高原地区发生547例出生缺陷患儿的临床资料,随机分为暴露组和非暴露组,暴露组302例,非暴露组245例,分别对比出生缺陷发生率,发生时间,诊断时间,终止妊娠情况进行临床分析。结果:暴露组出生缺陷发生率高于非暴露组,发生时间、诊断时间、终止妊娠时间均低于非暴露组。结论:高原地区围产期妇女所处环境,服用药物、接触的致畸因素很大程度上增加出生缺陷的发生率。
OBJECTIVE: To investigate the influence of perinatal women’s environment, taking drugs and teratogenic factors on the occurrence of birth defects in plateau areas. Methods: The clinical data of 547 children with birth defects from 2000 to 2007 in Qinghai Province were retrospectively analyzed. They were randomly divided into exposed group and non-exposed group, with 302 cases in exposed group and 245 cases in non-exposed group, respectively. Defect incidence, occurrence time, diagnosis time, termination of pregnancy for clinical analysis. Results: The incidence of birth defects in exposed group was higher than that in non-exposed group. The time of occurrence, diagnosis and termination of pregnancy were all lower than those in non-exposed group. CONCLUSIONS: The perinatal women in the plateau are exposed to teratogenic factors that greatly increase the incidence of birth defects in their environment, taking medication, and exposure.